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Rapidly Inducible Yeast Surface Display for Antibody Evolution with OrthoRep

25 Jul 2024

Abstract excerpt

We recently developed "autonomous hypermutation yeast surface display" (AHEAD), a technology that enables the rapid generation of potent and specific antibodies in yeast. AHEAD pairs yeast surface display with an error-prone orthogonal DNA replication system (OrthoRep) to continuously and rapidly mutate surface-displayed antibodies, thereby enabling enrichment for stronger binding variants through repeated rounds...

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PMID: 39052526
DOI: 10.1021/acssynbio.4c00370

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