Article

Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing

2019-09-19

Abstract excerpt

<h4>ABSTRACT</h4> The humanization of animal model immune systems by genetic engineering has shown great promise for antibody discovery, tolerance studies and for the evaluation of vaccines. Assessment of the baseline antibody repertoire of unimmunized model animals will be useful as a benchmark for future immunization experiments. We characterized the heavy chain and kappa chain antibody repertoires of a model a...

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Literature Corpus work: 9f8256db-63b3-54c8-b07f-ee28f3180576
DOI: 10.1101/776385

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