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Article

Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing.

Scientific reports - 24 Jan 2020

Joyce Collin, Burton Dennis R, Briney Bryan

Abstract excerpt

The humanization of animal model immune systems by genetic engineering has shown great promise for antibody discovery, tolerance studies and for the evaluation of vaccines. Assessment of the baseline antibody repertoires of unimmunized model animals will be useful as a benchmark for future immunization experiments. We characterized the heavy chain and kappa light chain antibody repertoires of a model animal, the...

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Identifiers

PMID: 31980672
DOI: 10.1038/s41598-020-57764-7
PMCID: PMC6981180

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