Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transferring the Characteristics of Naturally Occurring and Biased Antibody Repertoires to Human Antibody Libraries by Trapping CDRH3 Sequences

24 Aug 2012

Abstract excerpt

Antibody repertoires are characterized by diversity as they vary not only amongst individuals and post antigen exposure but also differ significantly between vertebrate species. Such plasticity can be exploited to generate human antibody libraries featuring hallmarks of these diverse repertoires. In this study, the focus was to capture CDRH3 sequences, as this region generally accounts for most of the interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to Protein purification and stability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22937053
DOI: 10.1371/journal.pone.0043471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transferring the Characteristics of Naturally Occurring and Biased Antibody Repertoires to Human Antibody Libraries by Trapping CDRH3 SequencesPMID 22937053Read ↗

Human antibody libraries: A race to engineer and explore a larger diversitySemantic proximity Read ↗

Reconciling the Structural Attributes of Avian AntibodiesSemantic proximity Read ↗

Discovery of diverse and functional antibodies from large human repertoire antibody librariesSemantic proximity Read ↗

A large human domain antibody library combining heavy and light chain CDR3 diversitySemantic proximity Read ↗

ALTHEA Gold Libraries™: antibody libraries for therapeutic antibody discoverySemantic proximity Read ↗

Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab LibrarySemantic proximity Read ↗

High-Resolution Description of Antibody Heavy-Chain Repertoires in HumansSemantic proximity Read ↗

Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platformsSemantic proximity Read ↗

Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoiresSemantic proximity Read ↗

Characterization of a high‐affinity human antibody with a disulfide bridge in the third complementarity‐determining region of the heavy chainSemantic proximity Read ↗

Structural and genetic diversity in antibody repertoires from diverse species.Semantic proximity Read ↗

CDR-H3 diversity is not required for antigen recognition by synthetic antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.