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Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets

16 Oct 2017

Abstract excerpt

Transgenic animal platforms for the discovery of human monoclonal antibodies have been developed in mice, rats, rabbits and cows. The immune response to human proteins is limited in these animals by their tolerance to mammalian-conserved epitopes. To expand the range of epitopes that are accessible, we have chosen an animal host that is less phylogenetically related to humans. Specifically, we generated...

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PMID: 29035625
DOI: 10.1080/19420862.2017.1386825

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