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Article

The functional repertoire of rabbit antibodies and antibody discovery via next-generation sequencing.

mAbs - 1 Jan 2000

Kodangattil Sreekumar, Huard Christine, Ross Cindy, Li Jian, Gao Huilan, Mascioni Alessandro, Hodawadekar Santosh, Naik Snehal, Min-debartolo Jessica, Visintin Alberto, Almagro Juan C

Abstract excerpt

To gain insight into the functional antibody repertoire of rabbits, the VH and VL repertoires of bone marrow (BM) and spleen (SP) of a naïve New Zealand White rabbit (NZW; Oryctolagus cuniculus) and that of lymphocytes collected from a NZW rabbit immunized (IM) with a 16-mer peptide were deep-sequenced. Two closely related genes, IGHV1S40 (VH1a3) and IGHV1S45 (VH4), were found to dominate (~90%) the VH repertoire...

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Identifiers

PMID: 24481222
DOI: 10.4161/mabs.28059
PMCID: PMC4011907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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