Article
Increased receptor binding and spike glycosylation, remodeled immune escape of surging SARS-CoV-2 subvariant BA.3.2.2/RE.2.2/Cicada.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2026
Li Linjie, Nguyen Linh, Qu Hao, Wu Qile, Gao Pengyue, Li Dedong, Li Xinyu, Liu Xueyuan, Jiang Qiuyao, Liu Kefang, Wong Catherine C L, Gao George Fu
Abstract excerpt
SARS-CoV-2 continues to evolve. The subvariant BA.3.2 (Cicada), a derivative of the Omicron BA.3 subtype first detected in late 2024, harbors multiple spike protein mutations, ORF7 and ORF8 deletions, and has recently evolved sublineages (BA.3.2.1 and BA.3.2.2), rendering it a critical target for epidemiological surveillance. The BA.3.2.2 sublineage, represented by RE.2.2, shows a marked upward trend in late...
Read the complete abstract on PubMedTopics
- Glycosylation
- Spike Glycoprotein, Coronavirus
- SARS-CoV-2
- Humans
- Immune Evasion