Article

Analysis of the SARS-CoV-2 spike protein glycan shield: implications for immune recognition

2020-04-09

Abstract excerpt

Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced in HEK293 cells. We also analyze structures for glycoforms representing those present in the nascent glycoproteins (prior to enzymatic modifications in the Golgi), as well as those that are commonly observed on antigens present in other viruse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fdb7632-b03d-55a7-a1b3-67a02629426c
DOI: 10.1101/2020.04.07.030445

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of the SARS-CoV-2 spike protein glycan shield: implications for immune recognitionDOI 10.1101/2020.04.07.030445Read

Site-specific analysis of the SARS-CoV-2 glycan shieldSemantic proximity Read

Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike ProteinSemantic proximity Read

Site-Specific Steric Control of SARS-CoV-2 Spike GlycosylationSemantic proximity Read

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 ReceptorSemantic proximity Read

Vulnerabilities in coronavirus glycan shields despite extensive glycosylationSemantic proximity Read

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human Ace2 ReceptorSemantic proximity Read

Structural remodeling of SARS-CoV-2 spike protein glycans reveals the regulatory roles in receptor-binding affinitySemantic proximity Read

Structural remodeling of SARS-CoV-2 spike protein glycans reveals the regulatory roles in receptor binding affinitySemantic proximity Read

Enhanced Surface Accessibility of SARS-CoV-2 Omicron Spike Protein Due to an Altered Glycosylation Profile.Semantic proximity Read

Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern.Semantic proximity Read

Identification of 22 N-glycosites on spike glycoprotein of SARS-CoV-2 and accessible surface glycopeptide motifs: Implications for vaccination and antibody therapeuticsSemantic proximity Read

Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody ProductionSemantic proximity Read