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Endoplasmic reticulum (ER) lumenal indicators in <i>Drosophila</i> reveal effects of HSP-related mutations on ER calcium dynamics

2020-02-20

Abstract excerpt

Genes for ER-shaping proteins are among the most commonly mutated in Hereditary Spastic Paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disruption, we developed tools to interrogate its Ca 2+ signaling function. We generated GAL4-driven Ca 2+ sensors targeted to the ER lumen, to r...

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Literature Corpus work
9f71f627-81b0-5c0b-8e01-afb229deabd5
DOI
10.1101/2020.02.20.957696
Open publication

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Endoplasmic reticulum (ER) lumenal indicators in <i>Drosophila</i> reveal effects of HSP-related mutations on ER calcium dynamicsDOI 10.1101/2020.02.20.957696
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