Article

Visualizing roles of spastic paraplegia proteins in organizing axonal ER in live Drosophila

2019-01-01

Abstract excerpt

Axons possess a continuous network of smooth tubular endoplasmic reticulum (ER), extending from the nuclear envelope throughout the neuron to synapses. Mutations affecting proteins with intramembrane hairpin domains that model tubular ER membrane can lead to the axon degenerative disease, hereditary spastic paraplegia (HSP). However, the extent and mechanisms by which HSP proteins contribute to axonal ER organizat...

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Literature Corpus work: f059dc3c-8bdc-59c7-ac74-8b416a12b24b
DOI: 10.17863/cam.37337

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