Article

Regulation of Eag by ca <sup>2+</sup> /calmodulin controls presynaptic excitability in <i>Drosophila</i>

2017-11-07

Abstract excerpt

Drosophila ether-à-go-go (eag ) is the founding member of a large family of voltage-gated K + channels, the KCNH family, which includes Kv10, 11 and 12, (Ganetzky et al. 1999). Concurrent binding of calcium/calmodulin (Ca 2+ /CaM) to N-and C-terminal sites inhibits mammalian EAG1 channels at sub-micromolar Ca 2+ concentrations (Schonherr et al. 2000), likely by causing pore constriction (Whicher and MacKinnon 2...

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Literature Corpus work: 8a86d2af-95dd-534e-b7f9-2065aea60990
DOI: 10.1101/215293

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