Article

<i>Drosophila</i> SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca <sup>2+</sup> dynamics

2021-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Neuronal endoplasmic reticulum (ER) appears continuous throughout the cell. Its shape and continuity are influenced by ER-shaping proteins, mutations in which can cause distal axon degeneration in Hereditary Spastic Paraplegia (HSP). We therefore asked how loss of Rtnl1 , a Drosophila ortholog of the human HSP gene RTN2 ( SPG12 ), which encodes an ER-shaping protein, affects ER organization...

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Literature Corpus work: 85945fa8-3115-5374-bf0c-affd75558e63
DOI: 10.1101/2021.12.17.473229

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