TMEM165 acts as a proton-activated Ca ²⁺ importer in lysosomes

Abstract excerpt

<h4>Summary</h4> Lysosomal calcium (Ca 2+ ) release is critical to cell signaling and is mediated by well-known lysosomal Ca 2+ channels. Yet, how lysosomes refill their Ca 2+ remains hitherto undescribed. Here, from an RNAi screen, we identify an evolutionarily conserved gene, lci-1 , that facilitates lysosomal Ca 2+ entry in C. elegans and in mammalian cells. Its human homolog TMEM165, previously designat...

Topics

Open a Topic to create a Post that cites this publication.

• Calcium signaling and nucleotide metabolism
• Intracellular Membranes
• Ion Channel Gating
• Lysosomes
• Membrane Potentials
• Pancreatic function and diabetes
• Permeability
• Protein Conformation

Identifiers and source

Literature Corpus work

0e97fb69-5d64-5a83-b032-5da9d3a495e7

DOI

10.1101/2023.08.08.552438