Article
Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins.
eLife - 25 Jul 2017
Yalçın Belgin, Zhao Lu, Stofanko Martin, O'Sullivan Niamh C, Kang Zi Han, Roost Annika, Thomas Matthew R, Zaessinger Sophie, Blard Olivier, Patto Alex L, Sohail Anood, Baena Valentina, Terasaki Mark, O'Kane Cahir J
Abstract excerpt
Axons contain a smooth tubular endoplasmic reticulum (ER) network that is thought to be continuous with ER throughout the neuron; the mechanisms that form this axonal network are unknown. Mutations affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP). We show that Drosophila axons have a dynamic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.