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P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance

10 Dec 2021

Abstract excerpt

B cell self-tolerance is maintained through multiple checkpoints, including restraints on intracellular signaling and cell trafficking. P2RY8 is a receptor with established roles in germinal center (GC) B cell migration inhibition and growth regulation. Somatic P2RY8 variants are common in GC-derived B cell lymphomas. Here, we identify germline novel or rare P2RY8 missense variants in lupus kindreds or the...

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PMID: 34889940
DOI: 10.1084/jem.20211004

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