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Article

Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes.

The American journal of pathology - 1 Oct 2009

Has Cristina, Herz Corinna, Zimina Elena, Qu Hai-Yan, He Yinghong, Zhang Zhi-Gang, Wen Ting-Ting, Gache Yannick, Aumailley Monique, Bruckner-Tuderman Leena

Abstract excerpt

Kindlin-1 is an epithelial-specific member of the novel kindlin protein family, which are regulators of integrin functions. Mutations in the gene that encodes Kindlin-1, FERMT1 (KIND1), cause the Kindler syndrome (KS), a human disorder characterized by mucocutaneous fragility, progressive skin atrophy, ulcerative colitis, photosensitivity, and propensity to skin cancer. Our previous studies indicated that loss of...

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Share to Skin Abnormalities
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19762715
DOI: 10.2353/ajpath.2009.090203
PMCID: PMC2751541

Genes

FERMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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