Article
SHARPIN is an endogenous inhibitor of β1-integrin activation.
Nature cell biology - 25 Sept 2011
Rantala Juha K, Pouwels Jeroen, Pellinen Teijo, Veltel Stefan, Laasola Petra, Mattila Elina, Potter Christopher S, Duffy Ted, Sundberg John P, Kallioniemi Olli, Askari Janet A, Humphries Martin J, Parsons Maddy, Salmi Marko, Ivaska Johanna
Abstract excerpt
Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are poorly defined. We identified SHARPIN as an important inactivator of β1-integrins in an RNAi screen. SHARPIN inhibited β1-integrin functions in human cancer cells and primary leukocytes. Fibroblasts, leukocytes and keratinocytes...
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