Article

Macrophage ferroptosis potentiates GCN2 deficiency induced pulmonary venous arterialization

2025-02-10

Abstract excerpt

Pulmonary veno-occlusive disease (PVOD) is a fatal disease characterized by the remodelling of pulmonary veins and haemosiderin accumulation in macrophages. Although GCN2 deficiency have been reported in PVOD patients, the underlying mechanism by which GCN2 deficiency affects the pulmonary venous cells and the surrounding cells, remains unclear. Here, we perform immunohistochemistry and scRNA-sequencing analyses t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b85a78aa-fbcb-50b1-b9d2-839308236676
DOI: 10.1101/2025.02.08.24318691

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Macrophage ferroptosis potentiates GCN2 deficiency induced pulmonary venous arterializationDOI 10.1101/2025.02.08.24318691Read

Identifying potential ferroptosis-related biomarkers and therapeutic targets for IPAH by integrative bioinformatics approachesSemantic proximity Read

Identification of Ferroptosis-related potential biomarkers and immunocyte characteristics in Chronic Thromboembolic Pulmonary Hypertension via bioinformatics analysisSemantic proximity Read

Identifying potential ferroptosis-related biomarkers and therapeutic targets for Idiopathic Pulmonary Hypertension in the context of predictive, preventive, and personalized medicine by integrative bioinformatics approachesSemantic proximity Read

EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension.Semantic proximity Read

Iron homeostasis governs erythroid phenotype in Polycythemia VeraSemantic proximity Read

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary HypertensionSemantic proximity Read

Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.Semantic proximity Read

Multi-Omics Exploration of the Role of PTGS2 as a Hub Gene in Ferroptosis Within the Artery of Takayasu ArteritisSemantic proximity Read

Iron homeostasis governs erythroid phenotype in polycythemia vera.Semantic proximity Read

Pulmonary Capillary Hemangiomatosis and Pulmonary Veno-occlusive Disease.Semantic proximity Read

Pulmonary veno-occlusive disease.Semantic proximity Read

Comparative Analyses of Lung Transcriptomes in Patients with Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins and in Foxf1 Heterozygous Knockout MiceSemantic proximity Read