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Article

Inhibition of angiogenesis by the secretome from iPSC-derived retinal ganglion cells with Leber's hereditary optic neuropathy-like phenotypes.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Sept 2024

Peng Shih-Yuan, Chen Chih-Ying, Chen Hsin, Yang Yi-Ping, Wang Mong-Lien, Tsai Fu-Ting, Chien Chian-Shiu, Weng Pei-Yu, Tsai En-Tung, Wang I-Chieh, Hsu Chih-Chien, Lin Tai-Chi, Hwang De-Kuang, Chen Shih-Jen, Chiou Shih-Hwa, Chiao Chuan-Chin, Chien Yueh

Abstract excerpt

The blood supply in the retina ensures photoreceptor function and maintains regular vision. Leber's hereditary optic neuropathy (LHON), caused by the mitochondrial DNA mutations that deteriorate complex I activity, is characterized by progressive vision loss. Although some reports indicated retinal vasculature abnormalities as one of the comorbidities in LHON, the paracrine influence of LHON-affected retinal...

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Identifiers

PMID: 39126773
DOI: 10.1016/j.biopha.2024.117270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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