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The Selective Glucocorticoid Receptor Modulator CORT125329 Decreases Neuroinflammation and Gliosis and Enhances Myelination in the Wobbler Model of Amyotrophic Lateral Sclerosis

2025-01-16

Abstract excerpt

<title>Abstract</title> <p>The Wobbler mouse is a genetic model of familial amyotrophic lateral sclerosis. Wobblers show spinal cord neurodegeneration associated with gliosis, neuroinflammation, and demyelination. Similar to human neurodegenerative diseases, Wobblers show high levels of corticosterone in blood and the nervous system. A role for glucocorticoids in neuropathology is suggested by the observation tha...

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Literature Corpus work
9f6281ea-8fb7-5ece-8002-622fbd228412
DOI
10.21203/rs.3.rs-5461870/v1
Open publication

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The Selective Glucocorticoid Receptor Modulator CORT125329 Decreases Neuroinflammation and Gliosis and Enhances Myelination in the Wobbler Model of Amyotrophic Lateral SclerosisDOI 10.21203/rs.3.rs-5461870/v1
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