Article

Synthetic analogue of adrenocorticotropic hormone, ACTH <sub>(4-7)</sub> PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination

2026-02-24

Abstract excerpt

<h4>Summary</h4> Mucopolysaccharidosis III (MPS III or Sanfilippo disease) is a spectrum of 4 genetic disorders (MPS IIIA-D), caused by defects in the genes SGSH, NAGLU, HGSNAT and GNS encoding enzymes involved in degradation of heparan sulfate (HS). HS accumulates in brain tissues and causes neuronal dysfunction and neurodegeneration leading to neuropsychiatric problems, developmental delays, childhood dementi...

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Literature Corpus work: b0404fae-e0b3-5239-8902-5f5494ac58d7
DOI: 10.64898/2026.02.20.707013

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Synthetic analogue of adrenocorticotropic hormone, ACTH <sub>(4-7)</sub> PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelinationDOI 10.64898/2026.02.20.707013Read

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