Article
The glucocorticoid receptor acts locally to protect dystrophic muscle and heart during disease.
Disease models & mechanisms - 1 May 2024
Oliver Trinitee, Nguyen Nhu Y, Tully Christopher B, McCormack Nikki M, Sun Christina M, Fiorillo Alyson A, Heier Christopher R
Abstract excerpt
Absence of dystrophin results in muscular weakness, chronic inflammation and cardiomyopathy in Duchenne muscular dystrophy (DMD). Pharmacological corticosteroids are the DMD standard of care; however, they have harsh side effects and unclear molecular benefits. It is uncertain whether signaling by physiological corticosteroids and their receptors plays a modifying role in the natural etiology of DMD. Here, we...
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