Article

The 11β-hydroxysteroid dehydrogenase type 1 inhibitor SPI-62 prevents morbidity in a mouse model of Cushing’s syndrome

2024-06-01

Abstract excerpt

11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitors represent a potential therapeutic approach for patients with Cushing’s syndrome, autonomous cortisol secretion (ACS), or iatrogenic glucocorticoid (GC) excess. We assessed whether the HSD-1 inhibitor SPI-62 prevents GC-associated morbidity in a mouse Cushing’s syndrome model. Corticosterone (CORT) was administered to mice for 5 weeks. Animals who received...

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Literature Corpus work: 8777e40e-c979-5e4d-b855-b5b93030bbd9
DOI: 10.1101/2024.05.27.596076

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