Article

Unveiling the conversion mechanism of glioblastoma from the mesenchymal to the proneural subtype driven by HDAC1/p-SMAD3-TP53I11 axis

2024-09-18

Abstract excerpt

<title>Abstract</title> <p>Mesenchymal glioblastoma (MES GBM) is characterized by rapid proliferation, extensive invasion, and formidable treatment resistance. Addressing these characteristics in MES cells is crucial for improving patient prognosis. Here, we discovered the MES GBM subtype conversion mechanism driven by HDAC1/p-SMAD3-TP53I11 in this study. First, the impact of HDAC1 inhibitors and bevacizumab on t...

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Literature Corpus work: 9f5c1f3e-7b9a-589f-944f-279e0b7de294
DOI: 10.21203/rs.3.rs-4733991/v1

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