Article

Inhibition of Mesenchymal Phenotypes in Glioblastoma by Combined Targeting of NF-κB and STAT3 Pathways

2024-10-25

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma, IDH-wildtype (GBM, WHO grade 4) is the most common and lethal type of brain cancer that is hard to cure. Among the 3 subtypes of GBM, the mesenchymal GBM is characterized by therapeutic resistance and poor outcomes. Here, we found that both STAT3 and NF-κB pathways are abnormally activated in mesenchymal GBM and the patients with higher expression of STAT3 and NF-κB had a...

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Literature Corpus work: a090c182-d468-5923-807d-2a789f6b2c79
DOI: 10.21203/rs.3.rs-5305574/v1

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