Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma

4 Jun 2019

Abstract excerpt

Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a prognosis of 12-15 months and just 3-5% of survival over 5 years. This is mainly because most patients suffer recurrence after treatment that currently consists in maximal resection followed by radio- and chemotherapy with temozolomide. The recurrent tumor shows a more aggressive behavior due to a phenotypic shift toward the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Glioma Diagnosis and Treatment
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31167470
DOI: 10.3390/ijms20112746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in GlioblastomaPMID 31167470Read ↗

The Role of Mesenchymal Reprogramming in Malignant Clonal Evolution and Intra-Tumoral Heterogeneity in GlioblastomaSemantic proximity Read ↗

Proneural-mesenchymal antagonism dominates the patterns of phenotypic heterogeneity in glioblastomaSemantic proximity Read ↗

The landscape of the mesenchymal signature in brain tumoursSemantic proximity Read ↗

Comprehensive understanding of glioblastoma molecular phenotypes: classification, characteristics, and transition.Semantic proximity Read ↗

Glioblastoma Heterogeneity and Cancer Cell PlasticitySemantic proximity Read ↗

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal TransitionSemantic proximity Read ↗

The significance of epithelial–mesenchymal transition (EMT) in the initiation, plasticity, and treatment of glioblastomaSemantic proximity Read ↗

Cell-Intrinsic and Cell-Extrinsic Therapeutic Targets in Glioblastoma: Overcoming Resistance Through Tumor Microenvironment Modulation and Precision MedicineSemantic proximity Read ↗

Cellular Plasticity and Tumor Microenvironment in Gliomas: The Struggle to Hit a Moving TargetSemantic proximity Read ↗

Epithelial-mesenchymal transition in glioblastoma progressionSemantic proximity Read ↗

Temozolomide Induces the Acquisition of Invasive Phenotype by O6-Methylguanine-DNA Methyltransferase (MGMT)+ Glioblastoma Cells in a Snail-1/Cx43-Dependent Manner.Semantic proximity Read ↗

Phenotypic variations in glioma stem cells: regulatory mechanisms and implications for therapeutic strategies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.