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Article

RUNX1 contributes to the mesenchymal subtype of glioblastoma in a TGFβ pathway-dependent manner

21 Nov 2019

Abstract excerpt

Runt-Related Transcription Factor 1 (RUNX1) is highly expressed in the Mesenchymal (Mes) subtype of glioblastoma (GBM). However, the specific molecular mechanism of RUNX1 in Mes GBM remains largely elusive. In this study, cell and tumor tissue typing were performed by RNA-sequencing. Co-immunoprecipitation (co-IP) and immunofluorescence (IF) were employed to identify members of the RUNX1 transcriptional protein...

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PMID: 31754093
DOI: 10.1038/s41419-019-2108-x

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