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Article

Smad3 and Smad4 mediate transforming growth factor-β1-induced IgA expression in murine B lymphocytes

1 Jun 2001

Abstract excerpt

Transforming growth factor (TGF)-beta1 is well established as a critical IgA isotype switching factor and Smad molecules have been reported to act as transducers and transcriptional factors in the expression of TGF-beta1-targeted genes. We examined the involvement of Smad proteins in TGF-beta1-induced IgA expression. First, we found that TGF-beta1 significantly increases endogenous germ-line (GL) alpha...

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PMID: 11385614
DOI: 10.1002/1521-4141(200106)31:6<1706::aid-immu1706>3.0.co;2-z

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