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Article

TGF-β1 induces germ-line transcripts of both IgA subclasses in human B lymphocytes

1 Jan 1991

Abstract excerpt

Immunoglobulin (Ig) class switching appears to be preceded by induction of germ-line transcripts. In this report, we demonstrate that transforming growth factor beta (TGF-beta) induces germ-line transcripts of both the IgA subclasses (IgA1 and IgA2) in Branhamella catarrhalis (BC)-activated human spleen B cells. Two germ-line bands, one of approximately 1.85 kb and the other of approximately 1.6 kb, could be seen...

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Identifiers

PMID: 1760405
DOI: 10.1093/intimm/3.11.1099

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