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Article

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993

Xu L, Gorham B, Li S C, Bottaro A, Alt F W, Rothman P

Abstract excerpt

Recent work has shown that the ability of cytokines to direct immunoglobulin heavy chain class-switch recombination to particular heavy chain constant (C) region (CH) genes correlates with the induction of specific germ-line CH transcripts. To test the role of germ-line transcripts in class switching, we have used homologous recombination to mutate the immunoglobulin heavy chain locus of the 18.81A20 murine...

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Identifiers

PMID: 8475119
DOI: 10.1073/pnas.90.8.3705
PMCID: PMC46370

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Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.PMID 8475119Read ↗

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