Article
Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993
Xu L, Gorham B, Li S C, Bottaro A, Alt F W, Rothman P
Abstract excerpt
Recent work has shown that the ability of cytokines to direct immunoglobulin heavy chain class-switch recombination to particular heavy chain constant (C) region (CH) genes correlates with the induction of specific germ-line CH transcripts. To test the role of germ-line transcripts in class switc...
Topics
- Abelson murine leukemia virus
- Alleles
- Animals
- B-Lymphocytes
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Cell Line
- Cell Line, Transformed
- DNA Probes
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunoglobulin epsilon-Chains
- Interleukin-4