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Article

PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma

31 Aug 2021

Abstract excerpt

Ovarian clear cell carcinoma (CCC) exhibits an association with endometriosis, resistance to oxidative stress, and poor prognosis owing to its resistance to conventional platinum-based chemotherapy. A greater understanding of the molecular characteristics and pathogenesis of ovarian cancer subtypes may facilitate the development of targeted therapeutic strategies, although the mechanism of drug resistance in...

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PMID: 34464482
DOI: 10.1111/cas.15125

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