Article

Multi-omics characterization of astrocyte subtypes reveals spatially coordinated astrocyte downregulation in depression

2026-07-03

Abstract excerpt

Major depressive disorder (MDD) is a complex psychiatric disorder affecting millions of individuals worldwide. Astrocytes, which have been implicated in MDD by several studies, are the most abundant non-neuronal cells in the brain and play critical roles in synaptic regulation, blood-brain barrier maintenance, and immune modulation. While astrocytic molecular and morphological abnormalities are well-established fe...

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Literature Corpus work: a0a76d1e-7128-57a8-963e-b3843a11b09c
DOI: 10.64898/2026.07.02.735636

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