Article

Circuit specific specialization of human basal ganglia astrocytes

2025-12-22

Abstract excerpt

<h4>SUMMARY</h4> Astrocytes shape synapses and circuits, yet human basal ganglia astrocyte diversity is incompletely defined. We built a multimodal atlas by integrating single-nucleus RNA-sequencing and chromatin accessibility with DNA methylation, 3D chromatin conformation, and spatial transcriptomics, then mapped basal ganglia programs onto a whole-brain reference. Astrocytes segregated into three anatomical su...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2225cb67-85d6-57e4-92b9-443374fe8f43
DOI: 10.64898/2025.12.19.695583

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Circuit specific specialization of human basal ganglia astrocytesDOI 10.64898/2025.12.19.695583Read

Multiscale Spatial Transcriptomic Atlas of Human Basal Ganglia Cell-Type and Cellular Community OrganizationSemantic proximity Read

A cross-species spatial transcriptomic atlas of the human and non-human primate basal gangliaSemantic proximity Read

Mesoscale molecular architecture of the human striatum across cell types and lifespanSemantic proximity Read

Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal GangliaSemantic proximity Read

Cross-species consensus atlas of the primate basal gangliaSemantic proximity Read

A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal GangliaSemantic proximity Read

A Multimodal Atlas Reveals the Anatomical Distribution of Medium Spiny Neuron Subtypes and a Novel RGS6+ Population in the Primate StriatumSemantic proximity Read

An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal GangliaSemantic proximity Read

Transcriptomic diversity of cell types across the adult human brainSemantic proximity Read

Cellular and genetic drivers of RNA editing variation in the human brainSemantic proximity Read

A Cross-Species Enhancer-AAV Toolkit for Cell Type-Specific Targeting Across the Basal GangliaSemantic proximity Read

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortexSemantic proximity Read