Article

Stress Induced Transcriptional and Epigenetic Plasticity of Astrocytes, Microglia and Oligodendrocytes in the Pathophysiology of Depression

2025-09-26

Abstract excerpt

Major Depressive Disorder (MDD) remains a leading cause of disability worldwide, perpetuated by an incomplete understanding of its pathophysiology and the limited efficacy of conventional antidepressants. For decades, research has been dominated by neuron-centric models, particularly the monoamine hypothesis. However, a paradigm shift is underway, placing glial cells such as astrocytes, microglia, and oligodendroc...

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Literature Corpus work: 1aa4bda5-9136-5c87-82d0-f60a7eae856a
DOI: 10.20944/preprints202509.2201.v1

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