Article

Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers <i>Skp2</i> function in metastasis, genomic instability and immune activation and reveals additional target pathways

2024-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Osteosarcoma (OS) is the most common primary pediatric bone malignancy. One promising new therapeutic target is SKP2 , encoding a substrate recognition factor of the SCF E3 ubiquitin ligase responsible for ubiquitination and proteasome degradation of substrate p27, thus driving cellular proliferation. We have shown previously that knockout of Skp2 in an immunocompetent transgenic mouse model o...

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Literature Corpus work: 9eb3ab42-92ee-57ce-8cdf-338170b88e8c
DOI: 10.1101/2024.06.04.597347

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