Article

Targeted inhibition of SCF <sup>SKP2</sup> confers anti-tumor activities resulting in a survival benefit in osteosarcoma

2023-05-14

Abstract excerpt

Osteosarcoma(OS) is a highly aggressive bone cancer for which treatment has remained essentially unchanged for decades. Although OS is characterized by extensive genomic heterogeneity and instability, RB1 and TP53 have been shown to be the most commonly inactivated tumor suppressors in OS. We previously generated a mouse model with a double knockout (DKO) of Rb1 and Trp53 within cells of the osteoblastic linea...

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Literature Corpus work: ad7aeff9-2933-52a8-b28c-78976c84bc0a
DOI: 10.1101/2023.05.13.540637

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