Article

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

2023-05-12

Abstract excerpt

<h4>Purpose</h4> Osteosarcoma (OS) is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in OS is SKP2 , encoding a substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that SKP2 knockout in murine OS improved survival and delayed tumorigenesis. Here we aim to define the SKP2 drives transcriptional program and its clinical implication in OS. <h4>...

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Literature Corpus work: a2d111ad-9e82-5382-80d3-282437148fd1
DOI: 10.1101/2023.05.09.540053

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