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Article

Whole-Exome Analysis and Osteosarcoma: A Game Still Open.

International journal of molecular sciences - 20 Dec 2024

Chiappetta Caterina, Della Rocca Carlo, Di Cristofano Claudio

Abstract excerpt

Osteosarcoma (OS) is the most prevalent malignant bone tumor in adolescents and young adults. OS cells grow in a permissive local microenvironment which modulates their behavior and facilitates all steps in tumor development (e.g., proliferation/quiescence, invasion/migration, and drug resistance) and contributes to their intrinsic heterogeneity. The lung parenchyma is the most common metastatic site in OS, and...

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Identifiers

PMID: 39769419
DOI: 10.3390/ijms252413657

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