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Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment

23 Nov 2022

Abstract excerpt

Osteosarcoma (OS) is a primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here, we comprehensively analyze genomic, epigenomic and transcriptomic data from 121 OS patients. Somatic mutations are diverse within the cohort, and only TP53 is significantly mutated. Through unsupervised integrative clustering of the multi-omics data, we classify OS into four subtypes with...

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PMID: 36418292
DOI: 10.1038/s41467-022-34689-5

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