Article

IDH1-dependent m6A methylation defines transcriptomic heterogeneity in glioma

2024-09-25

Abstract excerpt

Gliomas are biologically heterogeneous brain tumors with marked differences in clinical behavior based on the IDH1 mutation status. While epigenetic dysregulation is well characterized, the contribution of RNA modifications, particularly N6-methyladenosine (m6A), remains underexplored. Using direct RNA nanopore sequencing of patient-derived gliomas, we generated the first isoform-resolved m6A maps across IDH1-muta...

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Literature Corpus work: a9e4496e-143c-574a-9f20-4183b4ebafef
DOI: 10.1101/2024.09.24.24314089

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