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Deregulating m6A regulators leads to altered RNA biology in glioma cell lines

2024-10-30

Abstract excerpt

N6-methyladenosine (m6A) is the most prevalent internal mRNA modification, enriched in the CNS yet poorly characterized in glioma. Using long-read RNA sequencing, we mapped m6A in an in vitro glioma model following knockdown (KD) of the reader IGF2BP2, writer METTL3, and eraser ALKBH5, with naive glioma cells and astrocytes as controls. Glioma cells exhibited a two-fold reduction in global m6A, suggesting progres...

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Identifiers and source

Literature Corpus work
e07f5e09-cb0f-5a60-ab42-ec059cbdd9b2
DOI
10.1101/2024.10.28.620763
Open publication

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Deregulating m6A regulators leads to altered RNA biology in glioma cell linesDOI 10.1101/2024.10.28.620763
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