Article

Deep Sequencing Reveals Oligoclonality At The Immunoglobulin Locus In Multiple Myeloma Patients

2013-11-15

Abstract excerpt

Abstract Introduction Immunoglobulin (Ig) gene rearrangement is a hallmark of early B-cell development. Multiple myeloma (MM) is a malignancy of the plasma cells, which are at the terminal stage of B cell development. MM is a clonal disease originating from the transformation process of a single plasma cell and, thus, myeloma cells are traditionally thought to have one clonal Ig gene sequence that remains stable t...

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Literature Corpus work: 9e9ea3cf-d8bc-5e8f-9b6b-d78270b17f4e
DOI: 10.1182/blood.v122.21.401.401

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