A Next-Generation Sequencing Strategy for Evaluating the Most Common Genetic Abnormalities in Multiple Myeloma.

doi:10.1016/j.jmoldx.2016.08.004

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Article

A Next-Generation Sequencing Strategy for Evaluating the Most Common Genetic Abnormalities in Multiple Myeloma.

The Journal of molecular diagnostics : JMD - 1 Jan 2017

Jiménez Cristina, Jara-Acevedo María, Corchete Luis A, Castillo David, Ordóñez Gonzalo R, Sarasquete María E, Puig Noemí, Martínez-López Joaquín, Prieto-Conde María I, García-Álvarez María, Chillón María C, Balanzategui Ana, Alcoceba Miguel, Oriol Albert, Rosiñol Laura, Palomera Luis, Teruel Ana I, Lahuerta Juan J, Bladé Joan, Mateos María V, Orfão Alberto, San Miguel Jesús F, González Marcos, Gutiérrez Norma C, García-Sanz Ramón

Abstract excerpt

Identification and characterization of genetic alterations are essential for diagnosis of multiple myeloma and may guide therapeutic decisions. Currently, genomic analysis of myeloma to cover the diverse range of alterations with prognostic impact requires fluorescence in situ hybridization (FISH), single nucleotide polymorphism arrays, and sequencing techniques, which are costly and labor intensive and require...

Topics

Aged
DNA Mutational Analysis
Female
Gene Frequency
Genes, Neoplasm
High-Throughput Nucleotide Sequencing
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Diagnostic Techniques

Multiple Myeloma

Mutation

Source

Open in PubMed

Identifiers

PMID: 27863261
DOI: 10.1016/j.jmoldx.2016.08.004

Genes

IGH
BRAF
HRAS
KRAS
MYC
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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