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Article

Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma.

Oncotarget - 30 May 2015

Cowan Graeme, Weston-Bell Nicola J, Bryant Dean, Seckinger Anja, Hose Dirk, Zojer Niklas, Sahota Surinder S

Abstract excerpt

Human multiple myeloma (MM) is characterized by accumulation of malignant terminally differentiated plasma cells (PCs) in the bone marrow (BM), raising the question when during maturation neoplastic transformation begins. Immunoglobulin IGHV genes carry imprints of clonal tumor history, delineating somatic hypermutation (SHM) events that generally occur in the germinal center (GC). Here, we examine MM-derived...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25929340
DOI: 10.18632/oncotarget.3644
PMCID: PMC4537010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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