Article

A Bayesian approach for analysis of whole-genome bisulphite sequencing data identifies disease-associated changes in DNA methylation

2016-02-29

Abstract excerpt

<h4>ABSTRACT</h4> DNA methylation is a key epigenetic modification involved in gene regulation whose contribution to disease susceptibility remains to be fully understood. Here, we present a novel Bayesian smoothing approach (called ABBA) to detect differentially methylated regions (DMRs) from whole-genome bisulphite sequencing (WGBS). We also show how this approach can be leveraged to identify disease-associated...

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Literature Corpus work: 9e83502d-67f0-5a97-938b-958eb6ec3dcd
DOI: 10.1101/041715

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