Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID.

doi:10.1002/jmv.70275

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Article

Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID.

Journal of medical virology - 1 Mar 2025

Hansen Kristoffer Skaalum, Jørgensen Sofie Eg, Cömert Cagla, Schiøttz-Christensen Berit, Bross Peter, Agergaard Jane, Leth Steffen, Østergaard Lars, Palmfeldt Johan, Olsen Rikke Katrine Jentoft, Mogensen Trine H

Abstract excerpt

Long COVID represents a significant global health challenge with an unclear etiology. Alongside accumulating evidence of mitochondrial dysfunction in patients with acute SARS-CoV-2 infection, a symptomatic overlap exists between long COVID and mitochondrial disorders. However, the genetic underpinnings of mitochondrial dysfunction in long COVID have not been previously explored. We employed whole genome...

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Topics

Humans
Mitochondria
COVID-19
Male
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Energy Metabolism

Leukocytes, Mononuclear

Adult

SARS-CoV-2

Aged

Mitochondrial Diseases

Genetic Predisposition to Disease

Whole Genome Sequencing

Post-Acute COVID-19 Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 40025839
DOI: 10.1002/jmv.70275
PMCID: PMC11873671

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