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Determinants of trafficking, conduction, and disease within a K <sup>+</sup> channel revealed through multiparametric deep mutational scanning

2022-01-06

Abstract excerpt

A longstanding goal in protein science and clinical genetics is to develop quantitative models of sequence, structure, and function relationships and delineate the mechanisms by which mutations cause disease. Deep Mutational Scanning (DMS) is a promising strategy to map how amino acids contribute to protein structure and function and to advance clinical variant interpretation. Here, we introduce 7,429 single resid...

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Literature Corpus work
1b3afaf9-e693-559f-b8aa-bc0471344cd0
DOI
10.1101/2022.01.06.475280
Open publication

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Determinants of trafficking, conduction, and disease within a K <sup>+</sup> channel revealed through multiparametric deep mutational scanningDOI 10.1101/2022.01.06.475280
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