Article

Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs

2024-09-11

Abstract excerpt

Gout, a common and painful disease, stems from hyperuricemia, where elevated blood uric acid levels lead to urate crystal formation in joints and kidneys. The human urate transporter 1 (hURAT1) plays a critical role in urate homeostasis by facilitating urate reabsorption in the renal proximal tubule, making it a key target for gout therapy. Pharmacological inhibition of hURAT1 with drugs such as dotinurad, benzbro...

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Literature Corpus work: 9e5b053a-0751-572c-af3c-d7fe298666b1
DOI: 10.1101/2024.09.11.612394

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