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Article

<i>hURAT1</i> Transgenic Mouse Model for Evaluating Targeted Urate-Lowering Agents

2023-11-17

Abstract excerpt

<h4>Objective</h4> Urate transporter 1 (URAT1), a well-established urate-lowering therapeutic target for hyperuricemia and gout treatment, expresses in the kidney proximal tubule and is responsible for uric acid (UA) reabsorption. However, non-primate animal models currently used in pharmacological studies failed to evaluate URAT1 inhibitor’s effectiveness because their URAT1 has a very low UA affinity compared t...

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Identifiers and source

Literature Corpus work
39ef860f-7a62-572c-b1d4-1290d0a9b339
DOI
10.1101/2023.11.15.567192
Open publication

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<i>hURAT1</i> Transgenic Mouse Model for Evaluating Targeted Urate-Lowering AgentsDOI 10.1101/2023.11.15.567192
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