Article
[Molecular basis of primary renal hyperuricemia : role of the human urate transporter hURAT1].
Zeitschrift fur Rheumatologie - 1 Nov 2007
Unger S, Tausche A-K, Kopprasch S, Bornstein S R, Aringer M, Grässler J
Abstract excerpt
In highly industrialized countries hyperuricemia is one of the most common metabolic disorders. High uric acid blood levels may lead to the manifestation of gout owing to the precipitation of urate crystals in connective tissue, the skeletal system and kidneys. A primary reduction of renal uric acid excretion can be detected in more than 90% of all cases of hyperuricemia. Despite the identification of several...
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